Factor XIIa

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

Also Known As:

Coagulation Factor XIIa; Activated Factor XII; Blood Coagulation Factor XII, Activated; Factor 12A; Factor Twelve A; Hageman-Factor Fragments; Prekallikrein Activator; Activator, Prekallikrein; Factor XIIa, Coagulation; Fragments, Hageman-Factor; Hageman Factor Fragments; Factor XII, Activated

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Serine Proteases: 3808
        Serine Endopeptidases: 11
        Factor XIIa: 110
      - Endopeptidases: 643
        Serine Endopeptidases: 11
        Factor XIIa: 110
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Blood Coagulation Factors: 5500
      - Factor XII: 694
        Factor XIIa: 110
Biological Factors: 2560
- Blood Coagulation Factors: 5500
  - Factor XII: 694
    - Factor XIIa: 110

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Disease

Drug/Important Bio-Agent (IBA)